One night a couple months ago i was lying in bed about to sleep and then my body went numb and tingley and i started to breathe really heavily, i felt like i was out of breath and that i was going to ...
I am currently experiencing problems with dreadful pain in my lower legs which doesnt abate with rest, swelling of my hands and feet, sometimes severe difficulty swallowing. I have had two previous DV...
Different medications work differently. Some lower heart rate, others dilate arteries/veins. Others work by inhibiting angiotensin II(a substance that increases blood pressure).
depends what ones they are.They might be ones to lower cholestorol. What are they called?
Thiazides are diuretics that are derived from benzothiadiazine. They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. The chemical structure of the original thiazide diuretics contained a thiazide ring system; the term is also used for drugs with a similar action that are chemically thiazides, such as chlortalidone and metolazone.
Because of their vasodilator properties, Thiazides are often used to treat hypertension. They are the recommended first-line treatment in the US (JNC VII) guidelines and a recommended treatment in the European (ESC/ESH) guidelines. They have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by desensitizing the vascular smooth muscle cells to calcium release induced by norepinephrine (PMID 15611360).
Side effects can include hypokalemia, increased serum cholesterol, and impotence. The side effect of hypokalemia has motivated combining thiazides with ACE inhibitors, which also lower blood pressure but cause hyperkalemia as a side effect. Long-term usage of thiazides is also linked to increased levels of homocysteine, a toxic amino acid byproduct, has been associated with atherosclerosis. It is recommended that patients receiving long-term thiazide treatments also receive folic acid supplements to combat the risk.
Thiazides also lower urinary calcium excretion, making them useful in preventing calcium-containing kidney stones. This effect is associated with positive calcium balance and is associated with an increase in bone mineral density and reductions in fracture rates attributable to osteoporosis. Because of those properties, they are also used in the treatment of Dent's Disease or idiopathic hypercalciuria.
Thiazide may be combined with ACE inhibitors to increase diuresis without changing plasma potassium concentrations. While ACE inhibitors cause diuresis with potassium retention, thiazide increases potassium excretion. Their combined effects on potassium cancel each other out.
It should be noted that thiazides pass through breast milk, and in some cases, decrease the flow of breast milk. There is no specific information regarding the use of thiazides in children, but it is still advised that mothers avoid using thiazides during the first month of breast feeding.
Bendroflumethiazide is a thiazide derivative that affects reabsorption of electrolyte in the renal tubules. It increases excretion of sodium and chloride resulting in loss of potassium and bicarbonate. The exact mechanism as an anti-hypertensive is unknown .
Do they work? Yes.
Do they solve the actual problem?
No, it's known as a "Maintenance drug" and does nothing more than poison your body in a specific way in order to prevent you from having the symptom.
I say poison because all drugs must have a known toxic level (called an LD-50 which proves how much is lethal to 2 species of animals) before the drug can be approved.
This website link explains all about high blood pressure and the different types of medication available and how they work. I hope you get the information you are looking for.
Hypertension is sustained elevation of resting systolic BP (β‰¥ 140 mm Hg), diastolic BP (β‰¥ 90 mm Hg), or both. Hypertension with no known cause (primary; formerly, essential hypertension) is most common; hypertension with an identified cause (secondary hypertension) is usually due to a renal disorder. Usually, no symptoms develop unless hypertension is severe or long-standing. Diagnosis is by sphygmomanometry. Tests may be done to determine cause, assess damage, and identify other cardiovascular risk factors. Treatment involves lifestyle changes and drugs, including diuretics, Ξ²-blockers, ACE inhibitors, angiotensin II receptor blockers, and Ca channel blockers.
Bendroflumethiazide INN (formerly BAN bendrofluazide), is a thiazide diuretic, used to treat hypertension.
ok, i haven't researched it so this is a guess kind of, but i do think that they slow down your heart rate which in turn lowers your blood pressure.